{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:58:20Z","timestamp":1790816300478,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM119652"],"award-info":[{"award-number":["R35GM119652"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000165","name":"Division of Chemistry","doi-asserted-by":"publisher","award":["CHE-1654122"],"award-info":[{"award-number":["CHE-1654122"]}],"id":[{"id":"10.13039\/100000165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["ACI-1053575"],"award-info":[{"award-number":["ACI-1053575"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2018,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The trifluoromethoxy (OCF\n                    <jats:sub>3<\/jats:sub>\n                    ) radical is of great importance in organic chemistry. Yet, the catalytic and selective generation of this radical at room temperature and pressure remains a longstanding challenge. Herein, the design and development of a redox\u2010active cationic reagent (\n                    <jats:bold>1<\/jats:bold>\n                    ) that enables the formation of the OCF\n                    <jats:sub>3<\/jats:sub>\n                    radical in a controllable, selective, and catalytic fashion under visible\u2010light photocatalytic conditions is reported. More importantly, the reagent allows catalytic, intermolecular C\u2212H trifluoromethoxylation of a broad array of (hetero)arenes and biorelevant compounds. Experimental and computational studies suggest single electron transfer (SET) from excited photoredox catalysts to\n                    <jats:bold>1<\/jats:bold>\n                    resulting in exclusive liberation of the OCF\n                    <jats:sub>3<\/jats:sub>\n                    radical. Addition of this radical to (hetero)arenes gives trifluoromethoxylated cyclohexadienyl radicals that are oxidized and deprotonated to afford the products of trifluoromethoxylation.\n                  <\/jats:p>","DOI":"10.1002\/anie.201808495","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T16:17:58Z","timestamp":1537546678000},"page":"13795-13799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":137,"title":["Redox\u2010Active Reagents for Photocatalytic Generation of the OCF\n                    <sub>3<\/sub>\n                    Radical and (Hetero)Aryl C\u2212H Trifluoromethoxylation"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0170-4088","authenticated-orcid":false,"given":"Weijia","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Chemistry and Institute of Chemical Biology and Drug Discovery Stony Brook University  Stony Brook NY 11794 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0950-7815","authenticated-orcid":false,"given":"Johnny W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Institute of Chemical Biology and Drug Discovery Stony Brook University  Stony Brook NY 11794 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian A.","family":"Morales\u2010Rivera","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Pittsburgh  Pittsburgh PA 15260 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Pittsburgh  Pittsburgh PA 15260 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3055-6662","authenticated-orcid":false,"given":"Ming\u2010Yu","family":"Ngai","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Institute of Chemical Biology and Drug Discovery Stony Brook University  Stony Brook NY 11794 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,20]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr941147"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfluchem.2012.04.008"},{"key":"e_1_2_2_4_1","unstructured":"\u00a0"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201409375"},{"key":"e_1_2_2_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201409375"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04000"},{"key":"e_1_2_2_7_1","unstructured":"Synthesis of trifluoromethoxylated (hetero)aromatic compounds: for reviews see:"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.4.13"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201603697"},{"key":"e_1_2_2_9_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201603697"},{"key":"e_1_2_2_10_2","first-page":"313","volume":"27","author":"Lee K. 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