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Initially, a diverse target compound set was prepared by synthetic sequences based on chemoselective metal\u2010mediated couplings, including assembly of the furo[3,2\u2010b]pyridine scaffold by copper\u2010mediated oxidative cyclization. Optimization of the subseries containing 3,5\u2010disubstituted furo[3,2\u2010b]pyridines afforded potent, cell\u2010active, and highly selective inhibitors of CLKs. Profiling of the kinase\u2010inactive subset of 3,5,7\u2010trisubstituted furo[3,2\u2010b]pyridines revealed sub\u2010micromolar modulators of the Hedgehog pathway.<\/jats:p>","DOI":"10.1002\/anie.201810312","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T09:54:50Z","timestamp":1545299690000},"page":"1062-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Furo[3,2\u2010<i>b<\/i>]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway"],"prefix":"10.1002","volume":"58","author":[{"given":"V\u00e1clav","family":"N\u011bmec","sequence":"first","affiliation":[{"name":"Department of Chemistry, CZ-Openscreen Masaryk University  Kamenice 5 Brno 625 00 Czech Republic"},{"name":"International Clinical Research Centre St. Anne's University Hospital  Peka\u0159sk\u00e1 53 Brno 656 91 Czech 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