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In addition, cocaine accelerates exocytotic release dynamics while they remain unchanged after methylphenidate treatment. The parameters from pre\u2010spike feet for the two drugs are also in opposition, suggesting this aspect of release is affected differentially. As cocaine and methylphenidate are psychostimulants with similar pharmacologic action but have opposite effects on cognition, these results might provide a missing link between the regulation of exocytosis and vesicles and the effect of this regulation on cognition, learning, and memory. A speculative chemical mechanism of the effect of these drugs on vesicle content and exocytosis is presented.<\/jats:p>","DOI":"10.1002\/anie.201813717","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T11:35:16Z","timestamp":1548675316000},"page":"4238-4242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Combined Amperometry and Electrochemical Cytometry Reveal Differential Effects of Cocaine and Methylphenidate on Exocytosis and the Fraction of Chemical Release"],"prefix":"10.1002","volume":"58","author":[{"given":"Wanying","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Chemistry and Molecular Biology University of Gothenburg  Kemiv\u00e4gen 10 41296 Gothenburg Sweden"},{"name":"School of Pharmacy Nanjing Medical University  Longmian Avenue 101 Nanjing 210029 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