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The excellent stereoselectivity and broad scope for the transformation of substrates with pharmaceutically relevant heteroarenes render this method a practical and versatile approach for pyrrolidine synthesis. Additionally, this intramolecular hydroamination strategy facilitates the asymmetric synthesis of tetrahydroisoquinolines and medium\u2010ring dibenzo\u2010fused nitrogen heterocycles.<\/jats:p>","DOI":"10.1002\/anie.201814331","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T20:12:11Z","timestamp":1547928731000},"page":"3407-3411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Catalytic Asymmetric Synthesis of \u03b1\u2010Arylpyrrolidines and Benzo\u2010fused Nitrogen Heterocycles"],"prefix":"10.1002","volume":"58","author":[{"given":"Xi\u2010Jie","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Chemistry, Room 18-490 Massachusetts Institute of Technology  Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver D.","family":"Engl","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Room 18-490 Massachusetts Institute of Technology  Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Room 18-490 Massachusetts Institute of Technology  Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3875-4775","authenticated-orcid":false,"given":"Stephen L.","family":"Buchwald","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Room 18-490 Massachusetts Institute of Technology  Cambridge MA 02139 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