{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:48:35Z","timestamp":1785224915825,"version":"3.55.0"},"reference-count":71,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21572135"],"award-info":[{"award-number":["21572135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2019,3,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Auto\u2010tandem catalysis (ATC), in which a single catalyst promotes two or more mechanistically different reactions in a cascade pattern, provides a powerful strategy to prepare complex products from simple starting materials. Reported here is an unprecedented auto\u2010tandem cooperative catalysis (ATCC) for Morita\u2013Baylis\u2013Hillman carbonates from isatins and allylic carbonates using a simple Pd(PPh<jats:sub>3<\/jats:sub>)<jats:sub>4<\/jats:sub> precursor. Dissociated phosphine generates phosphorus ylides and the Pd leads to \u03c0\u2010allylpalladium complexes, and they undergo a \u03b3\u2010regioselective allylic\u2013allylic alkylation reaction. Importantly, a cascade intramolecular Heck\u2010type coupling proceeds to finally furnish spirooxindoles incorporating a 4\u2010methylene\u20102\u2010cyclopentene motif. Experimental results indicate that both Pd and phosphine play crucial roles in the catalytic Heck reaction. In addition, the asymmetric versions with either a chiral phosphine or chiral auxiliary are explored, and moderate results are obtained.<\/jats:p>","DOI":"10.1002\/anie.201814403","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T04:41:54Z","timestamp":1548823314000},"page":"4036-4040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Auto\u2010Tandem Cooperative Catalysis Using Phosphine\/Palladium: Reaction of Morita\u2013Baylis\u2013Hillman Carbonates and Allylic Alcohols"],"prefix":"10.1002","volume":"58","author":[{"given":"Peng","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Ouyang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Third Military Medical University  Chongqing 400038 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-0979","authenticated-orcid":false,"given":"Ying\u2010Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"},{"name":"College of Pharmacy Third Military Medical University  Chongqing 400038 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See the Supporting Information and Ref.\u2005[7] for more details."},{"key":"e_1_2_2_56_1","unstructured":"The structure of racemic3\u2009o(CCDC\u20051882576) was confirmed by X-ray analysis. These data can be obtained free of charge fromThe Cambridge Crystallographic Data Centre."},{"key":"e_1_2_2_57_1","unstructured":"For more details see the Supporting Information."},{"key":"e_1_2_2_58_1","unstructured":"Phosphonium salts have been used as pseudohalides in metal-catalyzed coupling reactions. 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