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Disclosed here is the first well\u2010defined model study for reactions between zinc(II) thiolate complexes and copper(II) complexes. Among all the studied ligands of copper(II), diethyldithiocarbamate (DTC) displays a unique redox\u2010tuning ability that enables copper(II) to resist the reduction by thiols while retaining its ability to oxidize zinc(II) thiolates to form disulfides. This work proves for the first time that it is possible to develop oxidants to discriminate between thiols and zinc(II) thiolates, alluding to a new chemical principle for how oxidants, especially universal anticancer Cu(DTC)<jats:sub>2<\/jats:sub>, might circumvent the intracellular reductive defense around certain zinc(II) thiolate sites of proteins to kill malignant cells.<\/jats:p>","DOI":"10.1002\/anie.201814519","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T10:26:49Z","timestamp":1551868009000},"page":"6070-6073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Universal Anticancer Cu(DTC)<sub>2<\/sub> Discriminates between Thiols and Zinc(II) Thiolates Oxidatively"],"prefix":"10.1002","volume":"58","author":[{"given":"Luyan","family":"Xu","sequence":"first","affiliation":[{"name":"School of Physical Science and Technology ShanghaiTech University  393 Middle Huaxia Road, Pudong new area Shanghai 201210 P. 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