{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:07:16Z","timestamp":1783512436383,"version":"3.55.0"},"reference-count":69,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM-118176"],"award-info":[{"award-number":["GM-118176"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2019,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This work bridges a gap in the cross\u2010coupling of aliphatic redox\u2010active esters with aryl zinc reagents. Previously limited to primary, secondary, and specialized tertiary centers, a new protocol has been devised to enable the coupling of general tertiary systems using nickel catalysis. The scope of this operationally simple method is broad, and it can be used to simplify the synthesis of medicinally relevant motifs bearing quaternary centers.<\/jats:p>","DOI":"10.1002\/anie.201814524","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T02:32:06Z","timestamp":1547001126000},"page":"2454-2458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Quaternary Centers by Nickel\u2010Catalyzed Cross\u2010Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents"],"prefix":"10.1002","volume":"58","author":[{"given":"Tie\u2010Gen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Chemistry Scripps Research  North Torrey Pines Road La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Scripps Research  North Torrey Pines Road La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel K.","family":"Mykhailiuk","sequence":"additional","affiliation":[{"name":"Department of Chemistry Scripps Research  North Torrey Pines Road La Jolla CA 92037 USA"},{"name":"Enamine Ltd.  Chervonotkatska 78 02094 Kyiv Ukraine"},{"name":"Taras Shevchenko National University of Kyiv Chemistry Department  Volodymyrska 64 01601 Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan R.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Chemistry Scripps Research  North Torrey Pines Road La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Chemistry Scripps Research  North Torrey Pines Road La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Scripps Research  North Torrey Pines Road La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9193-9053","authenticated-orcid":false,"given":"Phil S.","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Chemistry Scripps Research  North Torrey Pines Road La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"For an overview on metal-catalyzed cross-coupling reactions see:"},{"key":"e_1_2_2_2_2","volume-title":"Metal-catalyzed Cross-coupling Reactions","year":"1998"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471212466.ch14"},{"key":"e_1_2_2_4_2","volume-title":"Transition Metals for Organic Synthesis","year":"2004"},{"key":"e_1_2_2_5_1","unstructured":"\u00a0"},{"key":"e_1_2_2_6_2","volume-title":"The Logic of Chemical Synthesis","author":"Corey E. 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