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Herein, a multifunctional CuPc@HG@BN theranostic platform composed of hexagonal boron nitride nanosheets (h\u2010BNNS), conjugated DNA oligonucleotide, and copper(II) phthalocyanine (CuPc) was developed in which the CuPc molecule played double key roles in photodynamic therapy (PDT) as well as in\u2005situ monitoring and imaging of miR\u201021 by surface\u2010enhanced Raman spectroscopy (SERS). Owing to the designed circle amplification of miRNA and high SERS effects of CuPc on h\u2010BNNS, miR\u201021 responsive concentration was achieved as low as 0.7\u2005f\n                    <jats:sc>m<\/jats:sc>\n                    in live cells. Both in\u2005vitro and in\u2005vivo data demonstrated that the integrated nanoplatform showed remarkable enhancement in PDT efficiency with minimized damage to the normal tissues. The developed probe was also successfully utilized for early monitoring and guiding the early therapy, realizing tumor elimination.\n                  <\/jats:p>","DOI":"10.1002\/anie.201902776","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T03:01:14Z","timestamp":1554778874000},"page":"7757-7761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Functionalized h\u2010BN Nanosheets as a Theranostic Platform for SERS Real\u2010Time Monitoring of MicroRNA and Photodynamic Therapy"],"prefix":"10.1002","volume":"58","author":[{"given":"Jia","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Green Chemistry and Chemical Processes Department of Chemistry School of Chemistry and Molecular Engineering East China Normal University  Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry and Chemical Processes Department of Chemistry School of Chemistry and Molecular Engineering East China Normal University  Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-0349","authenticated-orcid":false,"given":"Yang","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry and Chemical Processes Department of Chemistry School of Chemistry and Molecular Engineering East China Normal University  Shanghai 200241 P. R. 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