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The potency of a novel triangular multinuclear complex containing three platinum atoms, <jats:bold>Pt\u20103<\/jats:bold>, towards breast cancer stem cells (CSCs) is reported. The trinuclear platinum(II) complex, <jats:bold>Pt\u20103<\/jats:bold> exhibits selective toxicity towards breast CSCs over bulk breast cancer cells and non\u2010tumorigenic breast cells. Remarkably, <jats:bold>Pt\u20103<\/jats:bold> inhibits the formation, size, and viability of mammospheres to a better extent than salinomycin, an established CSC\u2010potent agent, and cisplatin and carboplatin, clinically used platinum drugs. Mechanism of action studies show that <jats:bold>Pt\u20103<\/jats:bold> effectively enters breast CSCs, penetrates the nucleus, induces genomic DNA damage, and prompts caspase\u2010dependent apoptosis. 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