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Although significant advances in H<jats:sub>2<\/jats:sub>S up\u2010regulation, by the development of H<jats:sub>2<\/jats:sub>S donors, have been achieved in recent years, precise H<jats:sub>2<\/jats:sub>S down\u2010regulation is still challenging. The lack of potent\/specific inhibitors for H<jats:sub>2<\/jats:sub>S\u2010producing enzymes contributes to this problem. We expect the development of H<jats:sub>2<\/jats:sub>S scavengers is an alternative approach to address this problem. Since chemical sensors and scavengers of H<jats:sub>2<\/jats:sub>S share the same criteria, we constructed a H<jats:sub>2<\/jats:sub>S sensor database, which summarizes key parameters of reported sensors. Data\u2010driven analysis led to the selection of 30 potential compounds. Further evaluation of these compounds identified a group of promising scavengers, based on the sulfonyl azide template. 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