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Based on DFT calculations and electrochemical measurements, two probes, 3,4\u2010bis((2\u2010fluoro\u20105\u2010nitrobenzoyl)oxy)\u2010benzoic acid (M<jats:sub>PS\u20101<\/jats:sub>) and N\u2010(4\u2010(2,5\u2010dinitrophenoxy) phenyl)\u20105\u2010(1, 2\u2010dithiolan\u20103\u2010yl)pentanamide (M<jats:sub>HS\u20101<\/jats:sub>), were synthesized for specific recognition of H<jats:sub>2<\/jats:sub>S<jats:sub>n<\/jats:sub> and H<jats:sub>2<\/jats:sub>S. Through co\u2010assembly of the two probes at the mesoporous gold film with good anti\u2010biofouling ability and electrocatalytic activity, this microsensor showed high selectivity for H<jats:sub>2<\/jats:sub>S<jats:sub><jats:italic>n<\/jats:italic><\/jats:sub> and H<jats:sub>2<\/jats:sub>S against potential biological interferences. The biosensor can simultaneously determine the concentration of H<jats:sub>2<\/jats:sub>S<jats:sub><jats:italic>n<\/jats:italic><\/jats:sub> from 0.2 to 50\u2005\u03bc<jats:sc>m<\/jats:sc>, as well as that of H<jats:sub>2<\/jats:sub>S from 0.2 to 40\u2005\u03bc<jats:sc>m<\/jats:sc>. The expression of TRPA1 protein positively correlated with levels of H<jats:sub>2<\/jats:sub>S<jats:sub>n<\/jats:sub> under both ischemia and AD.<\/jats:p>","DOI":"10.1002\/anie.201907210","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T10:43:06Z","timestamp":1563532986000},"page":"13948-13953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Rational Design of Specific Recognition Molecules for Simultaneously Monitoring of Endogenous Polysulfide and Hydrogen Sulfide in the Mouse Brain"],"prefix":"10.1002","volume":"58","author":[{"given":"Hui","family":"Dong","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University  Dongchuan Road 500 Shanghai 200241 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