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While pathogenic effects have been linked to a highly conserved gene locus (\n                    <jats:italic>bur<\/jats:italic>\n                    \/\n                    <jats:italic>mal<\/jats:italic>\n                    ) in the\n                    <jats:italic>B. mallei<\/jats:italic>\n                    group, the metabolite associated to the encoded polyketide synthase, burkholderic acid (\n                    <jats:italic>syn<\/jats:italic>\n                    . malleilactone), could not explain the observed phenotypes. By metabolic profiling and molecular network analyses of the model organism\n                    <jats:italic>B. thailandensis<\/jats:italic>\n                    , the primary products of the cryptic pathway were identified as unusual cyclopropanol\u2010substituted polyketides. First, sulfomalleicyprols were identified as inactive precursors of burkholderic acid. Furthermore, a highly reactive upstream metabolite, malleicyprol, was discovered and obtained in two stabilized forms. Cell\u2010based assays and a nematode infection model showed that the rare natural product confers cytotoxicity and virulence.\n                  <\/jats:p>","DOI":"10.1002\/anie.201907324","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T02:30:40Z","timestamp":1564367440000},"page":"14129-14133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human\u2010 and Animal\u2010Pathogenic\n                    <i>Burkholderia<\/i>\n                    Species"],"prefix":"10.1002","volume":"58","author":[{"given":"Felix","family":"Trottmann","sequence":"first","affiliation":[{"name":"Department of Biomolecular Chemistry Leibniz Institute for Natural Product Research and Infection Biology (HKI)  Beutenbergstr. 11a 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7603-6232","authenticated-orcid":false,"given":"Jakob","family":"Franke","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, BMWZ Leibniz University Hannover  30167 Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Chemistry Leibniz Institute for Natural Product Research and Infection Biology (HKI)  Beutenbergstr. 11a 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Chemistry Leibniz Institute for Natural Product Research and Infection Biology (HKI)  Beutenbergstr. 11a 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cyrulies","sequence":"additional","affiliation":[{"name":"Department Bio Pilot Plant Leibniz Institute for Natural Product Research and Infection Biology (HKI)  07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Martin","family":"Dahse","sequence":"additional","affiliation":[{"name":"Department Infection Biology Leibniz Institute for Natural Product Research and Infection Biology (HKI)  07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Regestein","sequence":"additional","affiliation":[{"name":"Department Bio Pilot Plant Leibniz Institute for Natural Product Research and Infection Biology (HKI)  07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-337X","authenticated-orcid":false,"given":"Christian","family":"Hertweck","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Chemistry Leibniz Institute for Natural Product Research and Infection Biology (HKI)  Beutenbergstr. 11a 07745 Jena Germany"},{"name":"Natural Product Chemistry Faculty of Biological Sciences Friedrich Schiller University Jena  07743 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-131"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2016.1170598"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr007"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.01.005"},{"key":"e_1_2_2_5_1","first-page":"499","volume":"9","author":"Gilad J.","year":"2007","journal-title":"Isr. 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