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As this level decreases dramatically during the initial development of prostate cancer, in\u2005vivo detection of prostate zinc content may be applied for diagnosis of prostate cancer. Using <jats:sup>19<\/jats:sup>F ion chemical exchange saturation transfer magnetic resonance imaging (iCEST MRI) and TF\u2010BAPTA as a fluorinated Zn\u2010binding probe with micromolar sensitivity, we show that iCEST MRI is able to differentiate between normal and malignant prostate cells with a 10\u2010fold difference in contrast following glucose\u2010stimulated zinc secretion in\u2005vitro. The iCEST signal decreased in normal prostate cells upon downregulation of the ZIP1 zinc transporter. In\u2005vivo, using an orthotopic prostate cancer mouse model and a transgenic adenocarcinoma of the mouse prostate (TRAMP) model, a gradual decrease of &gt;300\u2009% in iCEST contrast following the transition of normal prostate epithelial cells to cancer cells was detected.<\/jats:p>","DOI":"10.1002\/anie.201909429","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T14:56:36Z","timestamp":1566312996000},"page":"15512-15517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Development of Zinc\u2010Specific iCEST MRI as an Imaging Biomarker for Prostate Cancer"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-8963","authenticated-orcid":false,"given":"Yue","family":"Yuan","sequence":"first","affiliation":[{"name":"The Russell H. 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