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However, currently available systems utilize \u201calways\u2010on\u201d photothermal transducers that lack target specificity, and thus inaccurately differentiate tumors from normal tissues. Developed here is a theranostic nanoplatform featuring H<jats:sub>2<\/jats:sub>S\u2010mediated in situ production of NIR photothermal agents for imaging\u2010guided and photocontrolled drug release. The system targets H<jats:sub>2<\/jats:sub>S\u2010rich cancers. This nanoplatform shows H<jats:sub>2<\/jats:sub>S\u2010activatable NIR\u2010II emission and NIR light controllable release of the drug Camptothecin\u201011. Upon administering the system to HCT116 tumor\u2010bearing mice, the tumor is greatly suppressed with minimal side effects, arising from the synergy of the cancer\u2010specific and NIR light activated therapy. This theranostic nanoplatform thus sheds light on precision medicine with guidance through NIR\u2010II imaging.<\/jats:p>","DOI":"10.1002\/anie.201909883","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T09:28:28Z","timestamp":1568798908000},"page":"16826-16830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":146,"title":["Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging\u2010Guided On\u2010Demand Drug Release"],"prefix":"10.1002","volume":"58","author":[{"given":"Ben","family":"Shi","sequence":"first","affiliation":[{"name":"Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology  Shanghai 200237 P. R. 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