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This method features a broad scope of both heterocyclic arenes (pyridine, quinoline, pyrazole, imidazole, furan, thiophene, benzofuran, and indole) and NH azaheterocycles (imidazole, pyrazole, indole, azindole, purine, indazole, benzimidazole, pyridone, carbazole), providing a versatile method for the synthesis of pharmaceutically important N\u2010(hetero)arylated heteroarenes. The versatility of this reaction was further demonstrated through late\u2010stage modification of marketed drugs and the synthesis of a key intermediate for accessing a class of angiotensin\u2005II receptor\u20051 antagonists.<\/jats:p>","DOI":"10.1002\/anie.201910395","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T05:44:41Z","timestamp":1571377481000},"page":"18141-18145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Cu\u2010Mediated Amination of (Hetero)Aryl C\u2212H bonds with NH Azaheterocycles"],"prefix":"10.1002","volume":"58","author":[{"given":"Jin\u2010Feng","family":"Yu","sequence":"first","affiliation":[{"name":"State key laboratory of organometallic chemistry Center for excellence in molecular synthesis Shanghai Institute of Organic Chemistry, CAS 345 Lingling Road Shanghai 200032 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Quan","family":"Yu","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute (TSRI) 10550 North Torrey Pines Road La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/9783527637737.ch8"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201002238"},{"key":"e_1_2_2_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201002238"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm200187y"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm501100b"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00407"},{"key":"e_1_2_2_7_1","unstructured":"Selected examples for bioactive molecules containing N-heteroarylated heteroarenes:"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2012.03.043"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr020059j"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603170"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm070245n"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.02.021"},{"key":"e_1_2_2_13_1","unstructured":"See top pharmaceutical posters by Njardarson's group athttps:\/\/njardarson.lab.arizona.edu\/content\/top-pharmaceuticals-poster."},{"key":"e_1_2_2_14_1","unstructured":"Reviews for synthesis ofN-arylated heteroarenes using aryl halides:"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr000664r"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.200404216"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0505268"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar800098p"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.200900587"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60289C"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00512"},{"key":"e_1_2_2_22_1","unstructured":"Selected examples for synthesis of N-arylated heteroarenes using arylboronic reagents:"},{"key":"e_1_2_2_23_2","first-page":"242","volume-title":"Chan-Lam Coupling Reaction: Copper-Promoted C-Element Bond Oxidative Coupling Reaction with Boronic Acids in Synthetic Methods in Drug Discovery, Vol.\u20051","author":"Lam P. 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