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The hybrid gels are composed of helical tri(ethylene glycol)\u2010functionalized polyisocyanides (PICs) and a conformation\u2010sensitive conjugated polythiophene, poly(3\u2010(3\u2032\u2010<jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010triethylammonium\u20101\u2032\u2010propyloxy)\u20104\u2010methyl\u20102,5\u2010thiophene chloride) (PMNT). The PIC polymer serves as a scaffold to trap and align the PMNT backbone into a highly ordered conformation, resulting in redshifted, new sharp bands in the absorption and fluorescence spectra. Similar to PIC, the hybrid closely mimics the mechanical properties of biological gels, such as collagen and fibrin, including the strain stiffening properties at low stresses. 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