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Now, a multicomponent reductive cross\u2010coupling involving an inorganic salt (sodium metabisulfite) for the straightforward construction of sulfones is disclosed. Both intramolecular and intermolecular reductive cross\u2010couplings were comprehensively explored, and diverse sulfones were accessible from the corresponding alkyl and aryl halides. Intramolecular cyclic sulfones were systematically obtained from five\u2010 to twelve\u2010membered rings. Naturally occurring aliphatic systems, such as steroids, saccharides, and amino acids, were highly compatible with the SO<jats:sub>2<\/jats:sub>\u2010insertion reductive cross\u2010coupling. Four clinically applied drug molecules, which include multiple heteroatoms and functional groups with active hydrogens, were successfully prepared via a late\u2010stage SO<jats:sub>2<\/jats:sub> insertion. Mechanistic studies show that alkyl radicals and sulfonyl radicals were both involved as intermediates in this transformation.<\/jats:p>","DOI":"10.1002\/anie.201911449","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T14:55:06Z","timestamp":1572533706000},"page":"1346-1353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":222,"title":["Multicomponent Reductive Cross\u2010Coupling of an Inorganic Sulfur Dioxide Surrogate: Straightforward Construction of Diversely Functionalized Sulfones"],"prefix":"10.1002","volume":"59","author":[{"given":"Yingying","family":"Meng","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular Engineering East China Normal University  3663 North Zhongshan Rd. Shanghai 200062 P. R. 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