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The synthesis of amphiphilic polyphenylene dendrimer branches (dendrons), providing alternating hydrophilic and lipophilic surface groups and one reactive ethynyl group at the core is reported. The amphiphilic surface groups serve as biorecognition units that bind to the surface of adenovirus\u20055 (Ad5), which is a common vector in gene therapy. The Ad5\/dendron complexes showed high gene transduction efficiencies in coxsackie\u2010adenovirus receptor (CAR)\u2010negative cells. Moreover, the dendrons offer incorporation of new functions at the dendron core by in situ post\u2010modifications, even when bound to the Ad5 surface. Surfaces coated with these dendrons were analyzed for their blood\u2010protein binding capacity, which is essential to predict their performance in the blood stream. 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