{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:04:20Z","timestamp":1790460260180,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2020,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Trypanosoma protozoan parasites are the causative agents of Chagas disease and sleeping sickness, two neglected tropical diseases where there is an urgent need for improved treatments and the evaluation of promising drug leads like the actinoallolides. Enabled by the highly stereocontrolled aldol reactions of three chiral ketone building blocks, an efficient first total synthesis of the potent anti\u2010trypanosomal macrolide (+)\u2010actinoallolide\u2005A has been achieved in 17 steps and 8\u2009% overall yield. Our convergent route features an adventurous ring\u2010closing metathesis to form the requisite trisubstituted (8\n                    <jats:italic>E<\/jats:italic>\n                    )\u2010alkene in the 12\u2010membered macrolactone, followed by the controlled installation of the labile transannular hemiacetal. Late\u2010stage diversification then provides ready access to the congeneric (+)\u2010actinoallolides\u2005B\u2013E.\n                  <\/jats:p>","DOI":"10.1002\/anie.201914042","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T15:41:25Z","timestamp":1574178085000},"page":"1572-1576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti\u2010Trypanosomal Macrolides"],"prefix":"10.1002","volume":"59","author":[{"given":"Matthew J.","family":"Anketell","sequence":"first","affiliation":[{"name":"University Chemical Laboratory University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore M.","family":"Sharrock","sequence":"additional","affiliation":[{"name":"University Chemical Laboratory University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-9136","authenticated-orcid":false,"given":"Ian","family":"Paterson","sequence":"additional","affiliation":[{"name":"University Chemical Laboratory University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000412"},{"key":"e_1_2_2_2_1","unstructured":"Chagas disease see:"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2015.12.017"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31612-4"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1410150"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2015.06.001"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001498"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31510-6"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60829-1"},{"key":"e_1_2_2_10_2","volume-title":"Trypanosomes and Trypanosomiasis","year":"2014"},{"key":"e_1_2_2_11_1","unstructured":"\u201cWHO. 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