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In PDT\u2010induced hypoxia, providing singlet oxygen from stored chemical energy may enhance the cell\u2010killing effect and boost the therapeutic effect. Herein, we present a phototheranostic (DPPTPE@PEG\u2010Py NPs) prepared by using a 2\u2010pyridone\u2010based diblock polymer (PEG\u2010Py) to encapsulate a semiconducting, heavy\u2010atom\u2010free pyrrolopyrrolidone\u2010tetraphenylethylene (DPPTPE) with high singlet\u2010oxygen\u2010generation ability both in dichloromethane and water. The PEG\u2010Py can trap the <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> generated from DPPTPE under laser irradiation and form a stable intermediate of endoperoxide, which can then release <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> in the dark, hypoxic tumor microenvironment. Furthermore, fluorescence\u2010imaging\u2010guided phototherapy demonstrates that this phototheranostic could completely inhibit tumor growth with the help of laser irradiation.<\/jats:p>","DOI":"10.1002\/anie.201914384","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T16:41:41Z","timestamp":1578933701000},"page":"8833-8838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":192,"title":["A Phototheranostic Strategy to Continuously Deliver Singlet Oxygen in the Dark and Hypoxic Tumor Microenvironment"],"prefix":"10.1002","volume":"59","author":[{"given":"Jianhua","family":"Zou","sequence":"first","affiliation":[{"name":"Key Laboratory of Flexible Electronics (KLOFE) &amp;, Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech)  30 South Puzhu Road Nanjing 211800 China"},{"name":"Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical 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