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Herein, we present a dual catalytic system for the N\u2010alkylation of diverse aromatic carbocyclic and heterocyclic amines directly with carboxylic acids, by\u2010passing their preactivation as redox\u2010active esters. The reaction, which is enabled by visible\u2010light\u2010driven, acridine\u2010catalyzed decarboxylation, provides access to N\u2010alkylated secondary and tertiary anilines and N\u2010heterocycles. Additional examples, including double alkylation, the installation of metabolically robust deuterated methyl groups, and tandem ring formation, further demonstrate the potential of the direct decarboxylative alkylation (DDA) reaction.<\/jats:p>","DOI":"10.1002\/anie.201916710","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T14:41:21Z","timestamp":1581518481000},"page":"7921-7927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":152,"title":["Visible\u2010Light\u2010Enabled Direct Decarboxylative N\u2010Alkylation"],"prefix":"10.1002","volume":"59","author":[{"given":"Vu T.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Chemistry The University of Texas at San Antonio  One UTSA Circle San Antonio TX 78249 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viet D.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Texas at San Antonio  One UTSA Circle San Antonio TX 78249 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham C.","family":"Haug","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Texas at San Antonio  One UTSA Circle San Antonio TX 78249 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan T. 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