{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:40:00Z","timestamp":1790674800060,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["642028"],"award-info":[{"award-number":["642028"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["TTU09.908"],"award-info":[{"award-number":["TTU09.908"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2020,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Elimination of pulmonary\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    (PA) infections is challenging to accomplish with antibiotic therapies, mainly due to resistance mechanisms. Quorum sensing inhibitors (QSIs) interfering with biofilm formation can thus complement antibiotics. For simultaneous and improved delivery of both active agents to the infection sites, self\u2010assembling nanoparticles of a newly synthesized squalenyl hydrogen sulfate (SqNPs) were prepared. These nanocarriers allowed for remarkably high loading capacities of hydrophilic antibiotic tobramycin (Tob) and a novel lipophilic QSI at 30\u2009% and circa 10\u2009%, respectively. The drug\u2010loaded SqNPs showed improved biofilm penetration and enhanced efficacy in relevant biological barriers (mucin\/human tracheal mucus, biofilm), leading to complete eradication of PA biofilms at circa 16\u2010fold lower Tob concentration than Tob alone. This study offers a viable therapy optimization and invigorates the research and development of QSIs for clinical use.\n                  <\/jats:p>","DOI":"10.1002\/anie.202001407","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T10:55:56Z","timestamp":1585911356000},"page":"10292-10296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of\n                    <i>P.\u2005aeruginosa<\/i>\n                    Biofilm Infections"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-6775","authenticated-orcid":false,"given":"Duy\u2010Khiet","family":"Ho","sequence":"first","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland Helmholtz Center for Infection Research  66123 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