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Cryogenic electron tomography provides complementary nanometer scale structural information to PL spectroscopy, but the two techniques have not been correlated due to technical challenges. Here, we present a method for correlating single\u2010particle information from these two powerful microscopy modalities. We simultaneously observe PL brightness, emission spectrum, and in\u2010plane excitation dipole orientation of CdSSe\/ZnS quantum dots suspended in vitreous ice. Stable and fluctuating emitters were observed, as well as a surprising splitting of the PL spectrum into two bands with an average energy separation of 80\u2005meV. In some cases, the onset of the splitting corresponded to changes in the in\u2010plane excitation dipole orientation. These dynamics were assigned to structures of individual quantum dots and the excitation dipoles were visualized in the context of structural features.<\/jats:p>","DOI":"10.1002\/anie.202002856","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T13:00:55Z","timestamp":1587733255000},"page":"15642-15648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cryogenic Correlative Single\u2010Particle Photoluminescence Spectroscopy and Electron Tomography for Investigation of Nanomaterials"],"prefix":"10.1002","volume":"59","author":[{"given":"Peter D.","family":"Dahlberg","sequence":"first","affiliation":[{"name":"Department of Chemistry Stanford University  Stanford CA 94305 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davis","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Chemistry Stanford University  Stanford CA 94305 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoming","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Stanford University  Stanford CA 94305 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wah","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Stanford University  Stanford CA 94305 USA"},{"name":"Division of CryoEM and Bioimaging, SSRL SLAC National Accelerator Laboratory  Menlo Park CA 94025 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2830-209X","authenticated-orcid":false,"given":"W. 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