{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:27:26Z","timestamp":1784208446112,"version":"3.55.0"},"reference-count":77,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2020,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A family of hybrid complexes combining two biologically active motifs, an artemisinin derivative and a cationic bis(NHC)\u2010gold(I) unit, has been synthesized. One of these complexes,\n                    <jats:bold>2\u2009a<\/jats:bold>\n                    , has been analyzed by single\u2010crystal X\u2010ray diffraction.\n                    <jats:bold>2\u2009a<\/jats:bold>\n                    shows strong anticancer activities on a large panel of human cancer cell models (prostate, breast, lung, liver, bladder, bone, acute and chronic myeloid leukemias) with GI\n                    <jats:sub>50<\/jats:sub>\n                    values in the n\n                    <jats:sc>m<\/jats:sc>\n                    range, together with a high selectivity. An original and distinctive mechanism of action, that is, through inhibition of the redox antioxidant NRF2 transcription factor (strongly associated with aggressiveness and resistance to cancer therapies) has been evidenced.\n                    <jats:bold>2\u2009a<\/jats:bold>\n                    could remarkably sensitize to sorafenib in HepG2 liver cells, in which dysregulated NRF2 signaling is linked to primary and acquired drug resistance.\n                    <jats:bold>2\u2009a<\/jats:bold>\n                    also inhibited NF\u2010\u03baB and HIF transcriptional activities, which are also associated with progression and resistance in cancer. Our findings provide evidence that hybrid (NHC)gold(I) compounds represent a new class of organometallic hybrid molecules that may yield new therapeutic agents.\n                  <\/jats:p>","DOI":"10.1002\/anie.202002992","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T10:09:07Z","timestamp":1587204547000},"page":"12062-12068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["An Artemisinin\u2010Derivative\u2013(NHC)Gold(I) Hybrid with Enhanced Cytotoxicity through Inhibition of NRF2 Transcriptional Activity"],"prefix":"10.1002","volume":"59","author":[{"given":"Chen","family":"Zhang","sequence":"first","affiliation":[{"name":"LCC-CNRS Universit\u00e9 de Toulouse CNRS, UPS  Toulouse France"},{"name":"Institut de Pharmacologie et de Biologie Structurale Universit\u00e9 de Toulouse CNRS, UPS  Toulouse France"},{"name":"Present address: Shanghai Key Laboratory of New Drug Design 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