{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:32:05Z","timestamp":1782369125920,"version":"3.54.5"},"reference-count":137,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21991121; 21421002"],"award-info":[{"award-number":["21991121; 21421002"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2020,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The increasing pharmaceutical importance of trifluoromethylarenes has stimulated the development of more efficient trifluoromethylation reactions. Tremendous efforts have focused on copper\u2010 and palladium\u2010mediated\/catalyzed trifluoromethylation of aryl halides. In contrast, no general method exists for the conversion of widely available inert electrophiles, such as phenol derivatives, into the corresponding trifluoromethylated arenes. Reported herein is a practical nickel\u2010mediated trifluoromethylation of phenol derivatives with readily available trimethyl(trifluoromethyl)silane (TMSCF<jats:sub>3<\/jats:sub>). The strategy relies on PMe<jats:sub>3<\/jats:sub>\u2010promoted oxidative addition and transmetalation, and CCl<jats:sub>3<\/jats:sub>CN\u2010induced reductive elimination. The broad utility of this transformation has been demonstrated through the direct incorporation of trifluoromethyl into aromatic and heteroaromatic systems, including biorelevant compounds.<\/jats:p>","DOI":"10.1002\/anie.202004116","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T02:01:13Z","timestamp":1590458473000},"page":"16076-16082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Nickel\u2010Mediated Trifluoromethylation of Phenol Derivatives by Aryl C\u2212O Bond Activation"],"prefix":"10.1002","volume":"59","author":[{"given":"Wei\u2010Qiang","family":"Hu","sequence":"first","affiliation":[{"name":"Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Science Chinese Academy of Sciences  345 Lingling Lu Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Science Chinese Academy of Sciences  345 Lingling Lu Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Science Chinese Academy of Sciences  345 Lingling Lu Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Vicic","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lehigh University  6 E. Packer Avenue Bethlehem PA 18015 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-756X","authenticated-orcid":false,"given":"Feng\u2010Ling","family":"Qing","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Science Chinese Academy of Sciences  345 Lingling Lu Shanghai 200032 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See:N. C.Bruno S. 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