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The chiral effects on living cells were investigated, and <jats:sc>d<\/jats:sc>\u2010Cu<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub>Co<jats:sub><jats:italic>y<\/jats:italic><\/jats:sub>S NPs showed about 2.5 times higher of internalized ability than <jats:sc>l<\/jats:sc>\u2010NPs. By modifying beta 2 macroglobulin (MG), senescent cells were effectively eliminated by <jats:sc>d<\/jats:sc>\u2010Cu<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub>Co<jats:sub><jats:italic>y<\/jats:italic><\/jats:sub>S NPs without damaging the activities of normal cells under AMF and photon illumination. Compared to the individual application of NIR illumination and AMF, their synergistic effect induced the production of caspase\u20103 with a much shorter treatment time and higher efficiency due to the more serious photon\u2010induced cellular redox and mechanical damage of cellular skeleton. Moreover, the developed strategy was successfully used to remove senescent cells in vivo. This study developed a controllable way of regulating cell activities using chiral NPs, which will provide a valuable way for treating diseases and promoting health.<\/jats:p>","DOI":"10.1002\/anie.202004575","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T08:49:45Z","timestamp":1589359785000},"page":"13915-13922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Chiral Cu<sub><i>x<\/i><\/sub>Co<sub><i>y<\/i><\/sub>S Nanoparticles under Magnetic Field and NIR Light to Eliminate Senescent Cells"],"prefix":"10.1002","volume":"59","author":[{"given":"Si","family":"Li","sequence":"first","affiliation":[{"name":"Key Lab of Synthetic and Biological Colloids, Ministry of Education, International Joint Research Laboratory for Biointerface and Biodetection Jiangnan University  Wuxi Jiangsu 214122 P. R. 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