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Traditional H bonds are ubiquitous in nature, yet the demonstration of weak H bonds that occur between a highly polarized C\u2212H group and an electron\u2010rich oxygen atom, has proven elusive. Detailed here are linear and nonlinear IR spectroscopy experiments that reveal the presence of H bonds between the chloroform C\u2212H group and an amide carbonyl oxygen atom in solution at room temperature. Evidence is provided for an amide solvation shell featuring two clearly distinguishable chloroform arrangements that undergo chemical exchange with a time scale of about 2\u2005ps. Furthermore, the enthalpy of breaking the hydrogen bond is found to be 6\u201320\u2005kJ\u2009mol<jats:sup>\u22121<\/jats:sup>. Ab\u2010initio computations support the findings of two distinct solvation shells formed by three chloroform molecules, where one thermally undergoes hydrogen\u2010bond making and breaking.<\/jats:p>","DOI":"10.1002\/anie.202006210","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T19:05:55Z","timestamp":1592593555000},"page":"17012-17017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Proving and Probing the Presence of the Elusive C\u2212H\u22c5\u22c5\u22c5O Hydrogen Bond in Liquid Solutions at Room Temperature"],"prefix":"10.1002","volume":"59","author":[{"given":"Susith R.","family":"Galle Kankanamge","sequence":"first","affiliation":[{"name":"Department of Chemistry Louisiana State University Baton Rouge LA 70803 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Louisiana State University Baton Rouge LA 70803 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Mackin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Tulane University New Orleans LA 70118 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fedra M.","family":"Leonik","sequence":"additional","affiliation":[{"name":"Department of Chemistry Louisiana State University Baton Rouge LA 70803 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6262-0796","authenticated-orcid":false,"given":"Carol M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Chemistry Louisiana State University Baton Rouge LA 70803 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-5905","authenticated-orcid":false,"given":"Igor V.","family":"Rubtsov","sequence":"additional","affiliation":[{"name":"Department of Chemistry Tulane University New Orleans LA 70118 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-7024","authenticated-orcid":false,"given":"Daniel G.","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Chemistry Louisiana State University Baton Rouge LA 70803 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_6_1_1","volume-title":"An introduction to hydrogen bonding","author":"Jeffrey G. 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