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While the hydrocupration of \u03b1,\u03b2\u2010unsaturated carbonyl compounds to form \u03b1\u2010cuprated species has been extensively investigated, we report herein that, in the presence of an appropriate ancillary chiral ligand, the opposite regiochemistry can be observed for cinnamic acid derivatives, leading to the delivery of the copper to the \u03b2\u2010position. This copper can react with an electrophilic aminating reagent, 1,2\u2010benzisoxazole, to provide enantioenriched \u03b2\u2010amino acid derivatives, which are important building blocks for the synthesis of natural products and bioactive small molecules.<\/jats:p>","DOI":"10.1002\/anie.202007005","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T17:55:18Z","timestamp":1593453318000},"page":"20841-20845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Enantioselective Synthesis of \u03b2\u2010Amino Acid Derivatives Enabled by Ligand\u2010Controlled Reversal of Hydrocupration Regiochemistry"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2542-0525","authenticated-orcid":false,"given":"Sheng","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Chemistry Massachusetts Institute of Technology  Cambridge MA 02139 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