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Nevertheless, \u03b1\u2010fluorination of \u03b1\u2010nonbranched carboxylic acid derivatives is still a big challenge because of relatively high p\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>a<\/jats:sub>\n                    values of their \u03b1\u2010hydrogen atoms and difficulty of subsequent synthetic transformation without epimerization. Herein we show that chiral copper(II) complexes of 3\u2010(2\u2010naphthyl)\u2010\n                    <jats:sc>l<\/jats:sc>\n                    \u2010alanine\u2010derived amides are highly effective catalysts for the enantio\u2010 and site\u2010selective \u03b1\u2010fluorination of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(\u03b1\u2010arylacetyl) and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(\u03b1\u2010alkylacetyl) 3,5\u2010dimethylpyrazoles. The substrate scope of the transformation is very broad (25\u2005examples including a quaternary \u03b1\u2010fluorinated \u03b1\u2010amino acid derivative). \u03b1\u2010Fluorinated products were converted into the corresponding esters, secondary amides, tertiary amides, ketones, and alcohols with almost no epimerization in high yield.\n                  <\/jats:p>","DOI":"10.1002\/anie.202007403","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T11:01:31Z","timestamp":1594119691000},"page":"17641-17647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Enantio\u2010 and Site\u2010Selective \u03b1\u2010Fluorination of\n                    <i>N<\/i>\n                    \u2010Acyl 3,5\u2010Dimethylpyrazoles Catalyzed by Chiral \u03c0\u2013Cu\n                    <sup>II<\/sup>\n                    Complexes"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4191-3845","authenticated-orcid":false,"given":"Kazuaki","family":"Ishihara","sequence":"first","affiliation":[{"name":"Graduate School of Engineering Nagoya University  B2-3(611), Furo-cho Chikusa Nagoya 464-8603 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Nagoya University  B2-3(611), Furo-cho Chikusa Nagoya 464-8603 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Nagoya University  B2-3(611), Furo-cho Chikusa Nagoya 464-8603 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