{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:29:59Z","timestamp":1791804599286,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","issue":"39","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2017YFC1309100 and 2017YFA0205200"],"award-info":[{"award-number":["2017YFC1309100 and 2017YFA0205200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671753, 91959124, 81227901, and 21804104"],"award-info":[{"award-number":["81671753, 91959124, 81227901, and 21804104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["JB191211, JB191207, JB191208"],"award-info":[{"award-number":["JB191211, JB191207, JB191208"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2020,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The blood\u2013brain barrier (BBB) restricts access to the brain of more than 98\u2009% of therapeutic agents and is largely responsible for treatment failure of glioblastoma multiforme (GBM). Therefore, it is of great importance to develop a safe and efficient strategy for more effective drug delivery across the BBB into the brain. Inspired by the extraordinary capability of rabies virus (RABV) to enter the central nervous system, we report the development and evaluation of the metal\u2013organic framework\u2010based nanocarrier MILB@LR, which closely mimicked both the bullet\u2010shape structure and surface functions of natural RABV. MILB@LR benefited from a more comprehensive RABV\u2010mimic strategy than mimicking individual features of RABV and exhibited significantly enhanced BBB penetration and brain tumor targeting. MILB@LR also displayed superior inhibition of tumor growth when loaded with oxaliplatin. The results demonstrated that MILB@LR may be valuable for GBM targeting and treatment.<\/jats:p>","DOI":"10.1002\/anie.202007474","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T07:47:28Z","timestamp":1593589648000},"page":"16982-16988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Rabies Virus\u2010Inspired Metal\u2013Organic Frameworks (MOFs) for Targeted Imaging and Chemotherapy of Glioma"],"prefix":"10.1002","volume":"59","author":[{"given":"Chaoqiang","family":"Qiao","sequence":"first","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Jia","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuo","family":"Yang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Xue","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renchuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufang","family":"Cui","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9388-149X","authenticated-orcid":false,"given":"Zhongliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61346-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014944"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.03.008"},{"key":"e_1_2_6_5_1","unstructured":"\u00a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.95.2.0190"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b06969"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201911896"},{"key":"e_1_2_6_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201911896"},{"key":"e_1_2_6_9_1","unstructured":"\u00a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.003"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.21"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.06.011"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801362"},{"key":"e_1_2_6_14_1","unstructured":"\u00a0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70326-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201101899"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618659114"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.21254"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07250-6"},{"key":"e_1_2_6_20_1","unstructured":"\u00a0"},{"key":"e_1_2_6_21_2","first-page":"360","volume":"83","author":"Knobel D.","year":"2005","journal-title":"Bull. World Health Organ."},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2207.151733"},{"key":"e_1_2_6_23_1","unstructured":"\u00a0"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2260"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2018.11"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.3.601"},{"key":"e_1_2_6_27_1","unstructured":"\u00a0"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.70"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.10.035"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm401129j"},{"key":"e_1_2_6_31_1","unstructured":"\u00a0"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja507833x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2014.169"},{"key":"e_1_2_6_34_1","unstructured":"\u00a0"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.094"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0091-7"},{"key":"e_1_2_6_37_1","unstructured":"\u00a0"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200704121"},{"key":"e_1_2_6_38_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200704121"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201707240"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b03705"},{"key":"e_1_2_6_41_1","unstructured":"\u00a0"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05901"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1505799112"},{"key":"e_1_2_6_44_1","unstructured":"\u00a0"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2608"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b00007"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201604381"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07392"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201911429"},{"key":"e_1_2_6_49_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201911429"},{"key":"e_1_2_6_50_1","unstructured":"\u00a0"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.12.5.1028-1030.1973"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2011.07.003"},{"key":"e_1_2_6_53_1","unstructured":"\u00a0"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b08172"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201605563"},{"key":"e_1_2_6_56_1","unstructured":"\u00a0"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2992"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12499"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900761"},{"key":"e_1_2_6_60_1","unstructured":"\u00a0"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2004.09.006"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.03.028"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201501779"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/b512169h"},{"key":"e_1_2_6_65_1","unstructured":"\u00a0"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201800817"},{"key":"e_1_2_6_66_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201800817"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC04147D"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119923"}],"updated-by":[{"DOI":"10.1002\/anie.3806134","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000}}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.202007474","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202007474","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202007474","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202007474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:10:30Z","timestamp":1693228230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202007474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,13]]},"references-count":72,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2020,9,21]]}},"alternative-id":["10.1002\/anie.202007474"],"URL":"https:\/\/doi.org\/10.1002\/anie.202007474","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,13]]},"assertion":[{"value":"2020-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}