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However, very few engineered nanoparticles can be excreted through salivary glands, which often host bacteria or viruses during infection and involve in disease transmission. Herein, we report that renal clearable glutathione coated AgNPs (GS\u2010AgNPs) can selectively accumulate in the submandibular salivary gland, followed by being excreted in its excretory duct. By conducting head\u2010to\u2010head comparison on in vivo transport and interactions of both GS\u2010AgNPs and glutathione coated gold nanoparticles (GS\u2010AuNPs) with the same sizes, we found that low\u2010density GS\u2010AgNPs showed much higher vascular permeability than GS\u2010AuNPs and can rapidly penetrate into submandibular salivary glands, be efficiently taken up by striated and excretory duct cells, and eventually secreted into saliva.<\/jats:p>","DOI":"10.1002\/anie.202008416","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T04:21:52Z","timestamp":1595564512000},"page":"19894-19898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Salivary Excretion of Renal\u2010Clearable Silver Nanoparticles"],"prefix":"10.1002","volume":"59","author":[{"given":"Shaoheng","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Chemistry The University of Texas at Dallas  800 W. 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