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By adding a zinc(II) phthalocyanine\u2010based photosensitizer (ZnPc) and the hypoxia\u2010inducible factor 1 (HIF\u20101) inhibitor acriflavine (ACF) during the Fe<jats:sup>3+<\/jats:sup>\u2010promoted self\u2010assembly of Fmoc\u2010protected cysteine (Fmoc\u2010Cys), the nanovesicles Fmoc\u2010Cys\/Fe@Pc and Fmoc\u2010Cys\/Fe@Pc\/ACF were prepared, which could be disassembled intracellularly. The released Fe<jats:sup>3+<\/jats:sup> could catalyze the transformation of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> enriched in cancer cells to oxygen efficiently, thereby ameliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc\u2010Cys\/Fe@Pc\/ACF exhibited higher in\u2005vitro and in\u2005vivo photodynamic activities than Fmoc\u2010Cys\/Fe@Pc, demonstrating the synergistic effect of ZnPc and ACF.<\/jats:p>","DOI":"10.1002\/anie.202010005","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T14:07:14Z","timestamp":1599142034000},"page":"23228-23238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Ferric Ion Driven Assembly of Catalase\u2010like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors"],"prefix":"10.1002","volume":"59","author":[{"given":"Yongxin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Tat Chee Avenue Kowloon Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Sun","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Green Process and Engineering Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7696-1487","authenticated-orcid":false,"given":"Xuehai","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9087-960X","authenticated-orcid":false,"given":"Dennis K. 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