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To better assess the therapeutic potential of their exogenous administration, we report on the development of a unique hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010sensing motif and its capacity for providing cellular protection against oxidative stress while serving as a reactive oxygen species (ROS)\u2010activated persulfide donor. With the strategic implementation of a\n                    <jats:italic>gem<\/jats:italic>\n                    \u2010dimethyl group to promote both stability and cyclization, we found the initial rate of payload release from this newly derived scaffold to be directly proportional to the concentration of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and to proceed via an unprecedented pathway that avoids the production of electrophilic byproducts, a severe limitation that has plagued the physiological application of previous designs.\n                  <\/jats:p>","DOI":"10.1002\/anie.202010530","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T02:50:08Z","timestamp":1598323808000},"page":"22238-22245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["An Innovative Hydrogen Peroxide\u2010Sensing Scaffold and Insight Towards its Potential as an ROS\u2010Activated Persulfide Donor"],"prefix":"10.1002","volume":"59","author":[{"given":"Rynne A.","family":"Hankins","sequence":"first","affiliation":[{"name":"Department of Chemistry Wake Forest University, Wake Downtown Campus  Winston-Salem NC 27101 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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