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A wide range of hetero(aryl)halides coupled with \u03b1,\u03b2\u2010unsaturated ketones, and transformation into the arylated products proceeded with excellent to good yields. The site selectivity of the reaction is switchable by simply changing the phosphine ligand to access either \u03b1\u2010arylated or \u03b3\u2010arylated products in good to excellent yields by using a low catalyst loading, and the method demonstrates good functional\u2010group compatibility.<\/jats:p>","DOI":"10.1002\/anie.202010682","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T12:22:11Z","timestamp":1601641331000},"page":"23438-23444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Ligand Control of Palladium\u2010Catalyzed Site\u2010Selective \u03b1\u2010 and \u03b3\u2010Arylation of \u03b1,\u03b2\u2010Unsaturated Ketones with (Hetero)aryl Halides"],"prefix":"10.1002","volume":"59","author":[{"given":"On Ying","family":"Yuen","sequence":"first","affiliation":[{"name":"Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery The Hong Kong Polytechnic University  Hung Hom Kowloon, Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-651X","authenticated-orcid":false,"given":"Chau Ming","family":"So","sequence":"additional","affiliation":[{"name":"Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery The Hong Kong Polytechnic University  Hung Hom Kowloon, Hong Kong Hong Kong"},{"name":"The Hong Kong Polytechnic University Shenzhen Research Institute  Shenzhen P. 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