{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:52:33Z","timestamp":1790495553266,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["QYZDJ-SSW-SLH052"],"award-info":[{"award-number":["QYZDJ-SSW-SLH052"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91856205, 21820102009"],"award-info":[{"award-number":["91856205, 21820102009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21533008, 21871249"],"award-info":[{"award-number":["21533008, 21871249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21877105"],"award-info":[{"award-number":["21877105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2021,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The COVID\u201019 pandemic caused by SARS\u2010CoV\u20102 has become a global threat. Understanding the underlying mechanisms and developing innovative treatments are extremely urgent. G\u2010quadruplexes (G4s) are important noncanonical nucleic acid structures with distinct biofunctions. Four putative G4\u2010forming sequences (PQSs) in the SARS\u2010CoV\u20102 genome were studied. One of them (RG\u20101), which locates in the coding sequence region of SARS\u2010CoV\u20102 nucleocapsid phosphoprotein (N), has been verified to form a stable RNA G4 structure in live cells. G4\u2010specific compounds, such as PDP (pyridostatin derivative), can stabilize RG\u20101 G4 and significantly reduce the protein levels of SARS\u2010CoV\u20102 N by inhibiting its translation both in vitro and in vivo. This result is the first evidence that PQSs in SARS\u2010CoV\u20102 can form G4 structures in live cells, and that their biofunctions can be regulated by a G4\u2010specific stabilizer. This finding will provide new insights into developing novel antiviral drugs against COVID\u201019.<\/jats:p>","DOI":"10.1002\/anie.202011419","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T03:17:43Z","timestamp":1600312663000},"page":"432-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":182,"title":["Targeting RNA G\u2010Quadruplex in SARS\u2010CoV\u20102: A Promising Therapeutic Target for COVID\u201019?"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1211-3873","authenticated-orcid":false,"given":"Chuanqi","family":"Zhao","sequence":"first","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science  Changchun Jilin 130022 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Qin","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science  Changchun Jilin 130022 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsheng","family":"Niu","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science  Changchun Jilin 130022 P. R. China"},{"name":"University of Science and Technology of China  Hefei Anhui 230026 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science  Changchun Jilin 130022 P. R. China"},{"name":"University of Science and Technology of China  Hefei Anhui 230026 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-627X","authenticated-orcid":false,"given":"Jinsong","family":"Ren","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science  Changchun Jilin 130022 P. R. China"},{"name":"University of Science and Technology of China  Hefei Anhui 230026 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2868-3205","authenticated-orcid":false,"given":"Xiaogang","family":"Qu","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science  Changchun Jilin 130022 P. R. China"},{"name":"University of Science and Technology of China  Hefei Anhui 230026 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.37"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31208-3"},{"key":"e_1_2_6_4_1","unstructured":"\u00a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc1560"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-020-01092-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0282-0"},{"key":"e_1_2_6_9_1","unstructured":"\u00a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv862"},{"key":"e_1_2_6_11_2","first-page":"1584","volume":"45","author":"Cammas A.","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja017308q"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3295"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200300589"},{"key":"e_1_2_6_14_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200300589"},{"key":"e_1_2_6_15_1","unstructured":"\u00a0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9178"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07490"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b00607"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-017-0041"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14432"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi4016692"},{"key":"e_1_2_6_23_1","first-page":"10343","volume":"44","author":"Artusi S.","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"e_1_2_6_24_1","unstructured":"\u00a0"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi400897g"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80170-1"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1479"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1501535"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku999"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky187"},{"key":"e_1_2_6_31_1","unstructured":"\u00a0"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01321-z"},{"key":"e_1_2_6_33_2","author":"Ji D.","year":"2020","journal-title":"Brief Bioinform."},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01583"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.0c01097"},{"key":"e_1_2_6_36_1","unstructured":"\u00a0"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2018.06.002"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl253"},{"key":"e_1_2_6_39_1","unstructured":"\u00a0"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.20.6097"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.849004"},{"key":"e_1_2_6_42_1","unstructured":"\u00a0"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv749"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8643"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep24793"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201914955"},{"key":"e_1_2_6_46_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201914955"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio864"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201709184"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201709184"},{"key":"e_1_2_6_49_1","unstructured":"\u00a0"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2012.05.003"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201900696"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf597"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa008"},{"key":"e_1_2_6_54_1","unstructured":"\u00a0"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1089\/154545703322860825"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr400113m"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku280"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1805"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/21690731.2016.1244031"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.11.027"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202011419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202011419","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202011419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T14:42:45Z","timestamp":1693752165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202011419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,4]]}},"alternative-id":["10.1002\/anie.202011419"],"URL":"https:\/\/doi.org\/10.1002\/anie.202011419","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"assertion":[{"value":"2020-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}