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Assessing the role of Lewis donor additives in these reactions revealed that N,N,N\u2032,N\u2032\u2032,N\u2032\u2032\u2010pentamethyldiethylenetriamine (PMDTA) finely tunes the regioselectivity of the Br\/Mg exchange on dibromo\u2010pyridines and quinolines. Combining spectroscopic with X\u2010ray crystallographic studies, light has been shed on the mixed Li\/Mg constitution of the organometallic intermediates accomplishing these transformations. These systems reacted effectively with a broad range of electrophiles, including allyl bromides, ketones, aldehydes, and Weinreb amides in good yields.<\/jats:p>","DOI":"10.1002\/anie.202012496","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T14:42:48Z","timestamp":1603204968000},"page":"1513-1518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Regioselective Bromine\/Magnesium Exchange for the Selective Functionalization of Polyhalogenated Arenes and Heterocycles"],"prefix":"10.1002","volume":"60","author":[{"given":"Alexandre","family":"Desaintjean","sequence":"first","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen Department Chemie  Butenandtstrasse 5\u201313, Haus F 81377 M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Haupt","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen Department Chemie  Butenandtstrasse 5\u201313, Haus F 81377 M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie J.","family":"Bole","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Chemie und Biochemie Universit\u00e4t Bern  3012 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil R.","family":"Judge","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Chemie und Biochemie Universit\u00e4t Bern  3012 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3998-7506","authenticated-orcid":false,"given":"Eva","family":"Hevia","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Chemie und Biochemie Universit\u00e4t Bern  3012 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7913-4332","authenticated-orcid":false,"given":"Paul","family":"Knochel","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen Department Chemie  Butenandtstrasse 5\u201313, Haus F 81377 M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ed1003806"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01409"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00606G"},{"key":"e_1_2_2_5_1","unstructured":"\u00a0"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/b611177g"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9004927"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201811380"},{"key":"e_1_2_2_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201811380"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16052"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja074060h"},{"key":"e_1_2_2_11_1","unstructured":"\u00a0"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200454084"},{"key":"e_1_2_2_12_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200454084"},{"key":"e_1_2_2_13_2","first-page":"40","volume":"26","author":"Murso A.","year":"2006","journal-title":"Spec. 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