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Despite its clinical relevance, delivery of H<jats:sub>2<\/jats:sub>S to biological systems is hampered by its toxicity at high concentrations. Herein, we report the first metal\u2010based H<jats:sub>2<\/jats:sub>S donor that delivers this gas selectively to hypoxic cells. We further show that H<jats:sub>2<\/jats:sub>S release from this compound protects H9c2 rat cardiomyoblasts from an in vitro model of ischemic reperfusion injury. 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