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Herein, an aptamer\u2010tethered deoxyribonucleic acids\u2010gold particle (Apt\u2010DNA\u2010Au) nanomachine has been developed for in situ imaging and targeted multimodal synergistic therapy of mammary carcinoma. Upon specifically internalized into MCF\u20107 cells, the tumor\u2010related TK1 mRNA activates the Apt\u2010DNA\u2010Au nanomachine by DNA strand displacement cascades, resulting in the release of the fluorophore and antisense DNA as well as the aggregation of AuNPs for in situ imaging, suppression of survivin expression and photothermal therapy, respectively. Meanwhile, the controlled released drugs are used for chemotherapy, while under the laser irradiation the loaded photosensitizer produces reactive oxygen species (ROS) for photodynamic therapy. 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