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By a library approach, a derivative that crystallizes as a conglomerate has been identified. Racemization occurs via reversible hydrogenation over a palladium on carbon (Pd\/C) packed column at 130\u2009\u00b0C, whereas deracemization is achieved by alternating crystal growth\/dissolution steps with temperature cycling between 5\u201315\u2009\u00b0C. These incompatible processes are combined by means of a flow system resulting in complete deracemization of the solid phase to the desired (<jats:italic>R<\/jats:italic>)\u2010enantiomer (98\u2009% <jats:italic>ee<\/jats:italic>). Such an unprecedented deracemization by a decoupled crystallization\/racemization approach can readily be turned into a practical process and opens new opportunities for the development of essential enantiomerically pure building blocks that require harsh methods for racemization.<\/jats:p>","DOI":"10.1002\/anie.202013502","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T12:53:14Z","timestamp":1606395194000},"page":"5279-5282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Combining Incompatible Processes for Deracemization of a Praziquantel Derivative under Flow Conditions"],"prefix":"10.1002","volume":"60","author":[{"given":"Giulio","family":"Valenti","sequence":"first","affiliation":[{"name":"Symeres  Kadijk 3 9747 AT Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3930-7056","authenticated-orcid":false,"given":"Paul","family":"Tinnemans","sequence":"additional","affiliation":[{"name":"Institute for Molecules and Materials Radboud University  Heyendaalseweg 135 6525 AJ Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4202-8947","authenticated-orcid":false,"given":"Iaroslav","family":"Baglai","sequence":"additional","affiliation":[{"name":"AMOLF  Science Park 104 1098 XG Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-2354","authenticated-orcid":false,"given":"Willem L.","family":"Noorduin","sequence":"additional","affiliation":[{"name":"AMOLF  Science Park 104 1098 XG Amsterdam The Netherlands"},{"name":"Van't Hoff Institute for Molecular Sciences, University of Amsterdam  Science Park 904 1090 GD Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-8657","authenticated-orcid":false,"given":"Bernard","family":"Kaptein","sequence":"additional","affiliation":[{"name":"InnoSyn BV  Urmonderbaan 22 6167 RD Geleen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8854-1084","authenticated-orcid":false,"given":"Michel","family":"Leeman","sequence":"additional","affiliation":[{"name":"Symeres  Kadijk 3 9747 AT Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-2160","authenticated-orcid":false,"given":"Joop H.","family":"ter Horst","sequence":"additional","affiliation":[{"name":"EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) Strathclyde Institute of Pharmacy and Biomedical Sciences, Technology and Innovation Centre University of Strathclyde  99 George Street Glasgow G1 1RD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-829X","authenticated-orcid":false,"given":"Richard M.","family":"Kellogg","sequence":"additional","affiliation":[{"name":"Symeres  Kadijk 3 9747 AT Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2011.01288.x"},{"key":"e_1_2_2_2_1","unstructured":"\u00a0"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001260"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02741-14"},{"key":"e_1_2_2_5_1","unstructured":"D.Maillard A.Waechtler J.Maurin E.Wakaresko C.Jasper PCT Int. 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