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The two\u2010dimensional MoS<jats:sub>2<\/jats:sub> \u201carrowhead\u201d configuration has a sharp edge structure that enables the vigorous extraction of lipids from cell membranes and subsequent membrane disruptions. In the presence of permonosulfate, a strong oxidant, sulfur vacancies containing MoS<jats:sub>2<\/jats:sub> activate the stable molecules, which in turn produce reactive oxygen species (ROS) from edge sites to basal areas. This process not only scavenges some portion of the phospholipids to allow for MoS<jats:sub>2<\/jats:sub> surface refreshment but also directly attacks proteins thereby inflicting further damage to injured cells and amplifying the cell\u2010membrane\u2010destructive stresses toward pathogenic microorganisms. With small amounts of the new material, we successfully disinfected natural water (\u224899.93\u2009% inactivation in terms of total bacteria) within 30\u2005s.<\/jats:p>","DOI":"10.1002\/anie.202013593","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T06:06:32Z","timestamp":1609394792000},"page":"7744-7751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Synergetic Lipid Extraction with Oxidative Damage Amplifies Cell\u2010Membrane\u2010Destructive Stresses and Enables Rapid Sterilization"],"prefix":"10.1002","volume":"60","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University  Beijing 100084 China"},{"name":"Key Laboratory of Drinking Water Science and Technology Research Centre for Eco- Environmental Sciences Chinese Academy of Sciences  Beijing 100085 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Ji","sequence":"additional","affiliation":[{"name":"Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6117-095X","authenticated-orcid":false,"given":"Gong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuhui","family":"Qu","sequence":"additional","affiliation":[{"name":"Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University  Beijing 100084 China"},{"name":"Key Laboratory of Drinking Water Science and Technology Research Centre for Eco- Environmental Sciences Chinese Academy of Sciences  Beijing 100085 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127291"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2015.141"},{"key":"e_1_2_6_4_1","unstructured":"\u00a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00578"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b00181"},{"key":"e_1_2_6_7_2","volume":"9","author":"Ding W. 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