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A unique diene\u2010platinum complex was identified to be an efficient catalyst, which enables direct metal\u2010enolate formation. The reaction operates under mild conditions without using strong bases or acids. Good to excellent yields can be achieved for diverse and complex scaffolds. A wide range of functional groups, including those sensitive to acids, bases\/nucleophiles, or palladium species, are tolerated, which represents a distinct feature from other known desaturation methods. Mechanistically, this platinum catalysis exhibits a fast and reversible \u03b1\u2010deprotonation followed by a rate\u2010determining \u03b2\u2010hydrogen elimination process, which is different from the prior Pd\u2010catalyzed desaturation method. Promising preliminary enantioselective desaturation using a chiral\u2010diene\u2010platinum complex has also been obtained.<\/jats:p>","DOI":"10.1002\/anie.202013628","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T18:36:43Z","timestamp":1610995003000},"page":"7956-7961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Platinum\u2010Catalyzed \u03b1,\u03b2\u2010Desaturation of Cyclic Ketones through Direct Metal\u2013Enolate Formation"],"prefix":"10.1002","volume":"60","author":[{"given":"Ming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Chicago  Chicago IL 60637 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-6015","authenticated-orcid":false,"given":"Guangbin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Chicago  Chicago IL 60637 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/B978-0-08-052349-1.00185-2","volume-title":"Comprehensive Organic Synthesis, Vol.\u20057","author":"Buckle D. 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