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The development of highly efficient chiral catalytic systems for kinetically controlled processes has therefore been one of the linchpins in asymmetric synthesis. N\u2010heterocyclic carbene (NHC)\/copper cooperative catalysis has enabled highly efficient KR and DyKAT of racemic<jats:italic>N<\/jats:italic>\u2010tosylaziridines by [3+3] annulation with isatin\u2010derived enals, leading to highly enantioenriched<jats:italic>N<\/jats:italic>\u2010tosylaziridine derivatives (up to &gt;99\u2009%<jats:italic>ee<\/jats:italic>) and a large library of spirooxindole derivatives with high structural diversity and stereoselectivity (up to &gt;95:5 d.r., &gt;99\u2009%<jats:italic>ee<\/jats:italic>). Mechanistic studies suggest that the NHC can bind reversibly to the copper catalyst without compromising its catalytic activity and regulate the catalytic activity of the copper complex to switch the chemoselection between KR and DyKAT.<\/jats:p>","DOI":"10.1002\/anie.202013679","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T15:26:00Z","timestamp":1603725960000},"page":"3268-3276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Kinetic Resolution of Aziridines Enabled by N\u2010Heterocyclic Carbene\/Copper Cooperative Catalysis: Carbene Dose\u2010Controlled Chemo\u2010Switchability"],"prefix":"10.1002","volume":"60","author":[{"given":"Zi\u2010Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry, and Center for Excellence in Molecular Synthesis of CAS University of Science and Technology of China Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hua","family":"Wen","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry, and Center for Excellence in Molecular Synthesis of CAS University of Science and Technology of China Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry, and Center for Excellence in Molecular Synthesis of CAS University of Science and Technology of China Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-827X","authenticated-orcid":false,"given":"Liu\u2010Zhu","family":"Gong","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry, and Center for Excellence in Molecular Synthesis of CAS University of Science and Technology of China Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","volume-title":"Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions","author":"Blaser H. 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