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The methyltransferases METTL3\u2010METTL14 and METTL16 act as \u201cwriters\u201d for different target transcripts and sequence motifs. The modification is perceived by dedicated \u201creader\u201d and \u201ceraser\u201d proteins, but not by polymerases. We report that METTL3\u201014 shows remarkable cosubstrate promiscuity, enabling sequence\u2010specific internal labeling of RNA without additional guide RNAs. The transfer of ortho\u2010nitrobenzyl and 6\u2010nitropiperonyl groups allowed enzymatic photocaging of RNA in the consensus motif, which impaired polymerase\u2010catalyzed primer extension in a reversible manner. METTL16 was less promiscuous but suitable for chemo\u2010enzymatic labeling using different types of click chemistry. 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