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Herein, we describe a palladium\u2010catalyzed room\u2010temperature deuterogenolysis of carbon\u2013oxygen bonds in alcohols and ketones with D\n                    <jats:sub>2<\/jats:sub>\n                    balloon for practical synthesis of deuterated pharmaceuticals and chemicals with benzyl\u2010site (sp\n                    <jats:sup>3<\/jats:sup>\n                    C\u2212H) D\u2010incorporation. The highlights of this deoxygenative deuteration strategy are mild conditions, broad scope, practicability and high chemoselectivity. To enable the direct use of D\n                    <jats:sub>2<\/jats:sub>\n                    O, electrocatalytic D\n                    <jats:sub>2<\/jats:sub>\n                    O\u2010splitting is adapted to in\u2005situ supply D\n                    <jats:sub>2<\/jats:sub>\n                    on demand. With this system, the precise incorporation of deuterium in the metabolic position (benzyl\u2010site) of ibuprofen is demonstrated in a sustainable and practical way with D\n                    <jats:sub>2<\/jats:sub>\n                    O.\n                  <\/jats:p>","DOI":"10.1002\/anie.202014196","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T06:12:32Z","timestamp":1608271952000},"page":"6357-6361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Room\u2010Temperature Palladium\u2010Catalyzed Deuterogenolysis of Carbon Oxygen Bonds towards Deuterated Pharmaceuticals"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3878-2592","authenticated-orcid":false,"given":"Wei","family":"Ou","sequence":"first","affiliation":[{"name":"International Collaborative Laboratory of 2D Materials for Optoelectronic Science &amp; Technology, Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong Province Institute of Microscale Optoelectronics Shenzhen University  Shenzhen 518060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Xiang","sequence":"additional","affiliation":[{"name":"International Collaborative Laboratory of 2D Materials for Optoelectronic Science &amp; Technology, Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong Province Institute of Microscale Optoelectronics Shenzhen University  Shenzhen 518060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zou","sequence":"additional","affiliation":[{"name":"International Collaborative Laboratory of 2D Materials for Optoelectronic Science &amp; Technology, Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong Province Institute of Microscale Optoelectronics Shenzhen University  Shenzhen 518060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Engineering Wenzhou University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian Ping","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8453-1938","authenticated-orcid":false,"given":"Chenliang","family":"Su","sequence":"additional","affiliation":[{"name":"International Collaborative Laboratory of 2D Materials for Optoelectronic Science &amp; Technology, Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong Province Institute of Microscale Optoelectronics Shenzhen University  Shenzhen 518060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.133.3446.102"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx800139z"},{"key":"e_1_2_2_3_1","unstructured":"\u00a0"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201704146"},{"key":"e_1_2_2_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201704146"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201708903"},{"key":"e_1_2_2_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201708903"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.01.010"},{"key":"e_1_2_2_7_1","unstructured":"\u00a0"},{"key":"e_1_2_2_8_2","first-page":"305","volume":"16","author":"Mullard A.","year":"2017","journal-title":"Nat. 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