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Experimental and theoretical investigations were performed to study the mechanism. In addition to initiating the reaction by proton abstraction, a more important role of TBD was revealed, that is, to enhance the oxidizing ability of peroxide intermediates, allowing DMSO to be used rather than commonly used phosphine reductants. Further characterizations with nuclear Overhauser effect spectroscopy (NOESY) confirmed the presence of double hydrogen bonds between TBD and the ketone, and kinetic studies suggested the attack of dioxygen on the TBD\u2010enol adduct to be the rate\u2010determining step. This work should encourage the application of TBD as a catalyst for oxidations.<\/jats:p>","DOI":"10.1002\/anie.202014478","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T06:43:08Z","timestamp":1606891388000},"page":"6631-6638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["1,5,7\u2010Triazabicyclo[4.4.0]dec\u20105\u2010ene Enhances Activity of Peroxide Intermediates in Phosphine\u2010Free \u03b1\u2010Hydroxylation of Ketones"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9153-8890","authenticated-orcid":false,"given":"Yongtao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemistry and ZJU-NHU United R&amp;D Center Zhejiang University  38 Zheda Road Hangzhou 310027 P. R. 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