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Reported here is a Cu\u2010catalyzed cascade reaction of \u03b1\u2010(hetero)aryl\u2010substituted alkyl (hetero)aryl ketones with primary amines that incorporates an unusual 1,2\u2010aryl migration induced by amide C\u2212N bond formation to produce a class of structurally novel \u03b1,\u03b1\u2010diaryl \u03b2,\u03b3\u2010unsaturated \u03b3\u2010lactams in generally good\u2010to\u2010excellent yields. This cascade reaction has a broad substrate scope with respect to primary amines, allows a wide spectrum of (hetero)aryl groups to smoothly undergo 1,2\u2010migration, and tolerates electronically diverse \u03b1\u2010substituents on the (hetero)aryl ring of the ketones. Mechanistically, this 1,2\u2010aryl migration may stem from the intramolecular amide C\u2212N bond formation which induces nucleophilic migration of the aryl group from the acyl carbon center to the electrophilic carbon center that is conjugated with the resulting iminium moiety.<\/jats:p>","DOI":"10.1002\/anie.202014900","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T06:39:41Z","timestamp":1610692781000},"page":"8425-8430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["1,2\u2010Aryl Migration Induced by Amide C\u2212N Bond\u2010Formation: Reaction of Alkyl Aryl Ketones with Primary Amines Towards \u03b1,\u03b1\u2010Diaryl \u03b2,\u03b3\u2010Unsaturated \u03b3\u2010Lactams"],"prefix":"10.1002","volume":"60","author":[{"given":"Rong","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Structural Chemistry Center for Excellence in Molecular Synthesis Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Yangqiao West Road 155 Fuzhou Fujian 350002 China"},{"name":"University of Chinese Academy of Sciences Beijing 100049 P. 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