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Various amplification strategies for chiral compounds to enhance a small chiral preference have been reported, but none of these involves phosphorylation, one of nature's essential chemical reactions. Here we present a simple and robust concept of phosphorylation\u2010based chiral amplification of amines and amino acids in water. By exploiting the difference in solubility of a racemic phosphoramidate and its enantiopure form, we achieved enantioenrichment in solution. Starting with near racemic, phenylethylamine\u2010based phosphoramidates, <jats:italic>ee's<\/jats:italic> of up to 95\u2009% are reached in a single amplification step. Particularly noteworthy is the enantioenrichment of phosphorylated amino acids and their derivatives, which might point to a potential role of phosphorus en\u2010route to prebiotic homochirality.<\/jats:p>","DOI":"10.1002\/anie.202014955","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T11:28:19Z","timestamp":1613734099000},"page":"11120-11126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Chiral Amplification of Phosphoramidates of Amines and Amino Acids in Water"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8696-2993","authenticated-orcid":false,"given":"Vanda","family":"Da\u0161kov\u00e1","sequence":"first","affiliation":[{"name":"Stratingh Institute for Chemistry University of Groningen  Nijenborgh 4 9747 AG Groningen The 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