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A particular focus has been the generation of organoboranes, organosilanes and organostannanes from simple hydrocarbons (X=B, Si, Sn). Despite the importance of organozinc compounds (X=Zn), their synthesis by the catalytic functionalisation of C\u2212H bonds remains unknown. Herein, we show that a palladium catalyst and zinc hydride reagent can be used to transform C\u2212H bonds into C\u2212Zn bonds. The new catalytic C\u2212H zincation protocol has been applied to a variety of arenes\u2014including fluoroarenes, heteroarenes, and benzene\u2014with high chemo\u2010 and regioselectivity. A mechanistic study shows that heterometallic Pd\u2013Zn complexes play a key role in catalysis. The conclusions of this work are twofold; the first is that valuable organozinc compounds are finally accessible by catalytic C\u2212H functionalisation, the second is that heterometallic complexes are intimately involved in bond\u2010making and bond\u2010breaking steps of C\u2212H functionalisation.<\/jats:p>","DOI":"10.1002\/anie.202014960","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T19:48:29Z","timestamp":1607111309000},"page":"6145-6153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Palladium\u2010Catalysed C\u2212H Bond Zincation of Arenes: Scope, Mechanism, and the Role of Heterometallic Intermediates"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3214-0150","authenticated-orcid":false,"given":"Mart\u00ed","family":"Gar\u00e7on","sequence":"first","affiliation":[{"name":"Molecular Sciences Research Hub Imperial College London  White City Campus, 82 Wood Lane, Shepherds Bush London W12 0BZ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette Wee","family":"Mun","sequence":"additional","affiliation":[{"name":"Molecular Sciences Research Hub Imperial College London  White City Campus, 82 Wood Lane, Shepherds Bush London W12 0BZ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J. 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