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This protocol provides unexpectedly fast access (usually 10\u2005min) to various chiral tertiary alcohols with exceptionally broad substrate scope and excellent functional group tolerance (76 examples, up to 98\u2009%\n                    <jats:italic>ee<\/jats:italic>\n                    ). This process is orthogonal to other known Ni\u2010mediated Suzuki\u2013Miyaura couplings, as it tolerates aryl chlorides, fluorides, ethers, esters, amides, nitriles, and alkyl chlorides. The reaction is applied to late\u2010stage modifications of various densely functionalized medicinally relevant molecules. Preliminary mechanistic studies suggest that a rare enantioselective \u03b7\n                    <jats:sup>2<\/jats:sup>\n                    \u2010coordinating activation of ketone carbonyls is involved. This cross\u2010coupling\u2010like mechanism is expected to enable other challenging transformations of ketones.\n                  <\/jats:p>","DOI":"10.1002\/anie.202015021","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T07:12:52Z","timestamp":1606374772000},"page":"5262-5267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Fast Enantio\u2010 and Chemoselective Arylation of Ketones with Organoboronic Esters Enabled by Nickel\/N\u2010Heterocyclic Carbene Catalysis"],"prefix":"10.1002","volume":"60","author":[{"given":"Yuan","family":"Cai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Lu Shanghai 200032 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