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Here we report an efficient electrochemical strategy for the selective upgrading of lignin derivatives to carboxylates by a manganese\u2010doped cobalt oxyhydroxide (MnCoOOH) catalyst. A wide range of lignin\u2010derived substrates with C(OH)\u2010C or C(O)\u2010C units undergo efficient cleavage to corresponding carboxylates in excellent yields (80\u201399\u2009%) and operational stability (200\u2005h). Detailed investigations reveal a tandem oxidation mechanism that base from the electrolyte converts secondary alcohols and their derived ketones to reactive nucleophiles, which are oxidized by electrophilic oxygen species on MnCoOOH from water. As proof of concept, this approach was applied to upgrade lignin derivatives with C(OH)\u2010C or C(O)\u2010C motifs, achieving convergent transformation of lignin\u2010derived mixtures to benzoate and KA oil to adipate with 91.5\u2009% and 64.2\u2009% yields, respectively.<\/jats:p>","DOI":"10.1002\/anie.202015431","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T16:25:11Z","timestamp":1612801511000},"page":"8976-8982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":211,"title":["Selectively Upgrading Lignin Derivatives to Carboxylates through Electrochemical Oxidative C(OH)\u2212C Bond Cleavage by a Mn\u2010Doped Cobalt Oxyhydroxide Catalyst"],"prefix":"10.1002","volume":"60","author":[{"given":"Hua","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Chemistry Tsinghua University  Beijing 100084 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